202420232022202120202019201820172016201520142013201220112010

2024

Chemistry for next-generation diagnostics: key factors in the development of medical biosensors

 M. Soler, L.M Lechuga

Metode Science Studies Journal, https://doi.org/10.7203/metode.15.27225

A novel biomimetic nanoplasmonic sensor for rapid and accurate evaluation of checkpoint inhibitor immunotherapy

 R. Batool, M. Soler, R. Singh, L.M Lechuga

Analytical and Bioanalytical Chemistry, https://doi.org/10.1007/s00216-024-05398-3

Plasmonic biosensors: towards fully operative detection platforms for biomedical application and its potential for the diagnosis of autoimmune diseases

 J.F. Giarola, M.-C. Estevez, L.M Lechuga

TrAC Trends in Analytical Chemistry, 176, 117763 https://doi.org/10.1016/j.trac.2024.117763

An α-helical peptide-based plasmonic biosensor for highly specific detection of α-synuclein toxic oligomers

 J.F. Giarola, J. Santos, M.-C. Estevez, S. Ventura, I. Pallarès, L.M Lechuga

Analytica Chimica Acta, 1304, 24, 342559 https://doi.org/10.1016/j.aca.2024.342559

Validation of a plasmonic-based serology biosensor for veterinary diagnosis of COVID-19 in domestic animals

 J.F. Giarola, M. Soler, M.-C. Estevez, A. Tarasova, S. Le Poder, M. Wasniewski, N. Decaro, L.M Lechuga

Talanta, 271, 125685  DOI:10.1016/j.talanta.2024.125685

2023

Integration of Metal–Organic Polyhedra onto a Nanophotonic Sensor for Real-Time Detection of Nitrogenous Organic Pollutants in Water

O. Calvo-Lozano, L. Hernández-López, L. Gomez, A. Carné-Sánchez, C. von Baeckmann, L.M Lechuga, D. Maspoch

ACS Applied Materials & Interfaces, 15 (33) 39523–39529   DOI: https://doi.org/10.1021/acsami.3c07213

Biomimetic nanoplasmonic sensor for rapid evaluation of neutralizing SARS-CoV-2 monoclonal antibodies as antiviral therapy

R. Batool, M. Soler, F. Colavita, L. Fabenia, G. Matusali, L. M. Lechuga

Biosensors and Bioelectronics.   DOI: http://10.1007/s00216-021-03751-4

2022

Using electrochemical immunoassay in a novel microtiter plate to detect surface markers of preclampsia on urinary extracellular vesicles

S. Lee, A. M. Gonzalez- Suarez, X. Huang, O. Calvo- Lozano, S. Suvakow, L.M. Lechuga, V. D. Garovic, G. Stybayeva, A. Revzin

ACS Sens.   DOI: http://10.1007/s00216-021-03751-4

Biochemistry strategies for label-free optical sensor biofunctionalization: advances towards real applicability

M. Soler, L.M. Lechuga

Anal.Bioanal Chem. 414, 5071- 5085  DOI: http://10.1007/s00216-021-03751-4

One-Step and Real-Time Detection of microRNA-21 in Human Samples for Lung Cancer Biosensing Diagnosis

O. Calvo-Lozano, P. García-Aparicio, L.Z Raduly, M.-C. Estévez, I. Berindan-Neagoe, M. Ferracin, L.M. Lechuga

Anal.Chem. 94, 14659-14665  DOI:10.1021/acs.analchem.2c02895

Rapid and direct quantification of the SARS-CoV-2 virus with an ultrasensitive nanobody-based
photonic nanosensor

G. Ruiz-Vega, M. Soler, M.-C.Estevez, P. Ramirez-Priego, M.D. Pazos, M.A. Noriega, Y. Margolles, C. Francés-Gómez, R. Geller, G. Matusali, F. Colavita,
A. di Caro, J.M. Casasnovas, L.A. Fernández, L.M. Lechuga

Sens. Diagn. 1, 983- 993 DOI:10.1039/d2sd00082b

Integrated optical bimodal waveguide biosensors: Principles and applications

L. Torrijos-Morán, B.D. Lisboa, M. Soler, L.M. Lechuga, J. García-Rupérez.

Results in Optics 9, 100285 DOI:10.1016/j.rio.2022.100285

Coating bioactive microcapsules with tannic acid enhances the phenotype of the encapsulated pluripotent stemm cells

D. Choi, K. Gwon, H.J. Hong, H. Baskaran, O. Calvo-Lozano, A.M. Gonzalez-Suarez, K. Park, J.M. de Hoyos-Vega, L.M. Lechuga, J. Hong, G. Stybayeva, A. Revzin

ACS Appl. Mater. Interfaces 14(23) 27274-27286 DOI:10.1021/acsami.2c06783

Label-Free Plasmonic Biosensor for Rapid, Quantitative and Highly Sensitive COVID-19 Serology: Implementation and Clinical Validation

O. Calvo-Lozano, M. Sierra, M. Soler, M.-C.Estévez, L. Chiscano-Camón, A. Ruiz-Sanmartin, J.C. Ruiz-Rodriguez, R. Ferrer, J.J. González-López, J. Esperalba, C. Fernández-Naval, L. Bueno, R. López-Aladid, A. Torres, L. Fernández-Barat, S. Attoumani, R. Charrel, B. Coutard, and L.M. Lechuga

Anal. Chem., 94 (2) 975–984, 975–984 – DOI: 10.1021/acs.analchem.1c03850

Novel Sensing Algorithm for Linear Read-out of Bimodal Waveguide Interferometric Biosensors

B. Bassols Cornudella, P. Ramirez-Priego, M. Soler, M.-C. Estevez, H. J. Luis-Ravelo, M.-C. Cardenosa-Rubio, Laura M. Lechuga

J. Lightwave Technol., 40 (1), 237-244 – DOI: 10.1109/JLT.2021.3118103

2021

Current Trends in SPR Biosensing of SARS-CoV-2 Entry Inhibitors

E. Mauriz, L. M. Lechuga

Chemosensors, 9(12), 330 – DOI: 10.3390/chemosensors9120330

Label-free plasmonic biosensor for rapid, quantitative, and highly sensitive COVID-19 serology: implementation and clinical validation

O. Calvo-Lozano, M. Sierra, M. Soler, M.-C. Estévez, L. Chiscano-Camón, A. Ruiz-Sanmartin, J. C. Ruiz-Rodriguez, R. Ferre, J. J. González-López, J. Esperalba, C. Fernández-Naval, L. Buen, R. López-Aladid, A. Torre, L. Fernández-Barat, S. Attoumani, R. Charrel, B. Coutard, L. M. Lechuga

ChemRxiv – DOI: doi.org/10.26434/chemrxiv.14595654.v1

Design and characterization of high-affinity synthetic peptides as bioreceptors for diagnosis of cutaneous leishmaniasis

Y. A. Prada, M. Soler, F. Guzmán, J. J. Castillo, L. M. Lechuga, E. Mejía-Ospino

Analytical Bioanalytical Chemistry, 413, 4545–4555 – DOI: 10.1007/s00216-021-03424-2

Plasmonic Biosensors for Single‐Molecule Biomedical Analysis

E. Mauriz, L. M. Lechuga

Biosensors, 11(4), 123 – DOI: 10.3390/bios11040123

Principles, technologies, and applications of plasmonic biosensors

M. Soler, L. M. Lechuga

Journal of Applied Physics, 129, 111102 – DOI: 10.1063/5.0042811

Nanophotonic biosensors for point-of-care COVID-19 diagnostics and coronavirus surveillance

G. Ruiz-Vega, M. Soler, L.M. Lechuga

J. Phys.: Photonics, 3, 011002 – DOI: 10.1088/2515-7647/abd4ee

Real-time monitoring of fenitrothion in water samples using a silicon nanophotonic biosensor

P. Ramirez-Priego, M.-C. Estévez, H.J. Díaz-Luisravelo, J.J. Manclús, Á. Montoya, L.M. Lechuga

Anal.Chim. Acta, 1152, 338276 – DOI: /10.1016/j.aca.2021.338276

2020

Coherent silicon photonic interferometric biosensor with an inexpensive laser source for sensitive label-free immunoassays

J. Leuermann, V. Stamenkovic, P. Ramirez-Priego, A. Sánchez-Postigo, A. Fernández-Gavela, C. A. Chapman, R. C. Bailey, L. M. Lechuga, E. Perez-Inestrosa, D. Collado, R. Halir, and I. Molina-Fernández

Optics Letters, 45, 6595-6598 – DOI: 10.1364/OL.411635

Ultrasensitive label-free detection of unamplified multidrug-resistance bacteria genes with a bimodal waveguide interferometric biosensor

J. Maldonado, A. B. González-Guerrero, A. Fernández-Gavela, J. J. González-López, L. M. Lechuga

Diagnostics, 10, 845 – DOI: 10.3390/diagnostics10100845

Engineering photonics solutions for COVID-19

M. Soler, A. Scholtz, Rene Zeto, A. M. Armani

APL Photonics – DOI: 10.1063/5.0021270

One-Step Immobilization of Antibodies and DNA on Gold Sensor Surfaces via a Poly-Adenine Oligonucleotide Approach

C. S. Huertas, M. Soler, M. -C. Estévez, L. M. Lechuga

Anal. Chem., 92(18), 12596-12604 – DOI: 10.1021/acs.analchem.0c02619

How Nanophotonic Label-Free Biosensors Can Contribute to Rapid and Massive Diagnostics of Respiratory Virus Infections: COVID-19 Case

M. Soler, M. -C. Estévez, M. Cardenosa- Rubio, A. Astúa, L. M. Lechuga

ACS Sensors, 5(9), 2663–2678 – DOI: 10.1021/acssensors.0c01180

Fast and Accurate Pneumocystis Pneumonia Diagnosis in Human Samples Using a Label-Free Plasmonic Biosensor

O. Calvo-Lozano, A. Aviñó, V. Friaza, A. Medina-Escuela, C. S. Huertas, E. J. Calderón, R. Eritja, L. M. Lechuga

Nanomaterials, 10, 1246 – DOI: 10.3390/nano10061246

Optical nanogap antennas as plasmonic biosensors for the detection of miRNA biomarkers

A. Portela, O. Calvo-Lozano, M.-C. Estévez, A. Medina-Escuela, L.M. Lechuga

Journal of Materials Chemistry B, 8, 4310-4317 – DOI: 10.1039/D0TB00307G

Detection and quantification of HspX antigen in sputum samples using plasmonic biosensing: toward a real Point-of-Care (POC) for tuberculosis diagnosis

E. Cristina Pelaez, M.- Carmen Estévez, A. Mongui, M-C. Menendez, C. Toro, O.L Herrera-Sandoval, J. Robledo, M.J Garcia, P. del Portillo, L.M Lechuga

ACS Infectious Diseases, 6 (5), 1110-1120 – DOI: 10.1021/acsinfecdis.9b00502

A compact SPR biosensor device for the rapid and efficient monitoring of gluten free diet directly in human urine

E. Cristina Peláez, M.-Carmen Estevez, Remedios Domínguez, Carolina Sousa, Angel Cebolla and Laura M. Lechuga

Analytical Bioanalytical Chemistry, 412, 6407–6417 – DOI: 10.1007/s00216-020-02616-6

Nanophotonic Biosensors: Driving Personalized Medicine

M. Soler, O. Calvo-Lozano, M.-C. Estevez, L. M. Lechuga

Optics & Photonics News, 31(4), 24-31

Label-free detection of nosocomial bacteria using a nanophotonic interferometric biosensor

J. Maldonado, M.-C. Estevez, A. Fernández Gavela, J.J. Gonzalez-Lopez, A.B. Gonzalez-Guerrero, L.M. Lechuga

Analyst, 145, 497-506 – DOI: 10.1039/C9AN01485C

2019

Boosting Cancer Immunotherapies with Optical Biosensor Nanotechnologies

M. Soler and L.M. Lechuga

European Medical Journal, 4, 124-132

Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors

C. S. Huertas, S. Bonnal, M. Soler, A. M. Escuela, J. Valcárcel, L. M. Lechuga

Analytical Chemistry, 91, 23, 15138-15146 – DOI: 10.1021/acs.analchem.9b03898

Lens-Free Interferometric Microscope for Point-of-Care Label-Free Detection of Sepsis Biomarkers

R.Terborg, L. Duempelmann, J. Pello, A. Noyan, F. Yesilkoy, A.A. Belushkin, Y. Jahani, N. Fabri-Faja, P. Dey, O. Calvo-Lozano, M.-C. Estevez, A. Fàbrega, J.J. González-López, L.M Lechuga, H. Altug, V. Pruneri

Frontiers in Optics, FM3F. 6, 2019 – DOI: 10.1364/FIO.2019.FM3F.6

Advanced Evanescent-Wave Optical Biosensors for the Detection of Nucleic Acids: An Analytic Perspective

C. Huertas, O. Calvo-Lozano, A. Mitchell, L. M. Lechuga

Frontiers in Chemistry, 7, 724, 2019 – DOI: 10.3389/fchem.2019.00724

Advances in nanoplasmonic biosensors for clinical applications

E. Mauriz, P. Dey, L. M. Lechuga

Analyst, 144, 7105-7129, 2019 – DOI: 10.1039/C9AN00701F

Label-free, scalable and point-of-care imaging platform for rapid analysis of biomarker

L. Duempelmann, R. A. Terborg, J. Pello, I. Mannelli, F. Yesilkoy, A. A. Belushkin, Y. Jahani, N. Fabri-Faja, P. Dey, O. Calvo-Lozano, M. C. Estevez, A. Fàbrega, J. J. González-López, L. M. Lechuga, H. Altug, V. Pruneri

Proc. SPIE 11076, Advances in Microscopic Imaging II, 11076, 1107619, 2019 – DOI: 10.1117/12.2525878

Trimodal Waveguide Demonstration and its Implementation as a High Order Mode Interferometer for Sensing Application

J. C. Ramirez, L. H. Gabrielli, L. M. Lechuga, H. E. Hernandez-Figueroa

Sensors, 19, 2821, 2019 – DOI: 10.3390/s19122821

Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices

J. Leuermann, A. Fernández-Gavela, A. Torres-Cubillo, S. Postigo, A. Sánchez-Postigo, L. M. Lechuga, R. Halir, I. Molina-Fernández

Sensors, 19(17), 3671, 2019 – DOI: 10.3390/s19176371

Low-cost vertical taper for high efficient light in-coupling in bimodal nanointerferometric waveguide biosensors

D. Grajales, A. Fernández Gavela, C. Domínguez, J. R. Sendra, L. M. Lechuga

Journal of Physics: Photonics, 1(2), 25002, 2019 – DOI: 10.1088/2515-7647/aafebb

Low-cost and portable UV holographic microscope for high-contrast protein crystal imaging

M. U. Daloglu, A. Ray, M. J. Collazo, C. Brown , D. Tseng, B. Chocarro-Ruiz, L. M. Lechuga, D. Cascio, A. Ozcan

APL Photonics, 4, 030804, 2019 – DOI: 10.1063/1.5080158

Label-free plasmonic biosensors for point-of-care diagnostics: a review

M. Soler, C. S. Huertas, L. M. Lechuga

Expert Review of Molecular Diagnostics, 19(1), 71-81, 2019 – DOI: 10.1080/14737159.2019.1554435

Label-free bacteria quantification in blood plasma by a bioprinted microarray based interferometric point-of-care device

P. Dey, N. Fabri-Faja, O. Calvo-Lozano, R. Terborg, A. Belushkin, F. Yesilköy, A. Fàbrega, J. C. Ruiz-Rodriguez, R. Ferrer, J. J. González-López, M. C. Estévez, H. Altug, V. Pruneri, L. M. Lechuga

ACS Sensors, 4, 52-60, 2019 – DOI: 10.1021/acssensors.8b00789

Full integration of photonic nanoimmunosensors inportable platforms for on-line monitoring of ocean pollutants

A. Fernandez-Gavela, S. Herranz, B. Chocarro, F. Falke, E. Schreuder, H. Leeuwis, R. G. Heideman, L. M. Lechuga

Sensors and Actuators B: Chemical, 297, 126758, 2019 – DOI: 10.1016/j.snb.2019.126758

Early Sepsis Diagnosis via Protein and miRNA Biomarkers using a novel Point-of-Care Photonic Biosensor

N. Fabri-Faja, O. Calvo-Lozano, P. Dey, R. A. Terborg, M. C. Estévez, A. Belushkin, F. Yesilköy, L. Duempelmann, H. Altug, V. Pruneri, L. M. Lechuga

Analytica Chimica Acta, 1077, 232-242, 2019 – DOI: 10.1016/j.aca.2019.05.038

Dispositius avançats per al nanodiagnòstic clínic

M. C. Estevez and L. M. Lechuga

Treballs de la Societat Catalana de Biologia, 2019

Building of a flexible microfluidic plasmo-nanomechanical biosensor for live cell analysis

V. Solis-Tinoco, S. Marquez, T. Quesada-Lopez, F. Villarroya, A. Homs-Corbera, L. M. Lechuga

Sensors and Actuators B: Chemical, 291, 48-57, 2019 – DOI: 10.1016/j.snb.2019.04.038

Aptamer-peptide conjugates as a new strategy to modulate human α-thrombin binding affinity

A. Aviñó, A. F. Jorge, C. S. Huertas, T. F. G. G. Cova, A. Pais, L. M. Lechuga, R. Eritja, C. Fabrega

Biochimica et Biophysica Acta (BBA) – General Subjects, 1863(10), 1619-1630, 2019 – DOI: 10.1016/j.bbagen.2019.06.014

2018

Low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine

D. Martens, P. Ramirez-Priego, M. S. Murib, A. A. Elamin, A. B. Gonzalez-Guerrero, M. Stehr, F. Jonas, B. Anton, N. Hlawatsch, P. Soetaert, R. Vos, A. Stassen, S. Severi, W. Van Roy, R. Bockstaele, H. Becker, M. Singh, L. M. Lechuga, P. Bienstman

Analytical Methods, 10, 3066-3073, 2018 – DOI: 10.1039/C8AY00666K

Nanoplasmonic biosensor device for the monitoring of acenocoumarol therapeutic drug in plasma

E. C. Peláez, M. C. Estévez, A. Portela, J. P. Salvador, M. P. Marco, L. M. Lechuga

Biosensors and Bioelectronics, 119, 149-155, 2018 – DOI: 10.1016/j.bios.2018.08.011

Label-free DNA-methylation detection by direct ds-DNA fragment screening using poly-purine hairpins

C. S. Huertas, A. Aviñó, C. Kurachi, A. Piqué, J. Sandoval, R. Eritja, M. Esteller, L. M. Lechuga

Biosensors and Bioelectronics, 120, 47-54, 2018 – DOI: 10.1016/j.bios.2018.08.027

Label-free and real-time detection of tuberculosis in human urine samples using a nanophotonic point-of-care platform

P. Ramirez-Priego, D. Martens, A. A. Elamin, P. Soetaert, W. Van Roy, R. Vos, B. Anton, R. Bockstaele, H. Becker, M. Singh, P. Bienstman, L. M. Lechuga

ACS Sensors, 3, 2079-2086, 2018 – DOI: 10.1021/acssensors.8b00393

Interferometric nanoimmunosensor for label-free and real-time monitoring of Irgarol 1051 in seawater

B. Chocarro-Ruiz, S. Herranz, J. Sanchís, M. Farré, M. P. Marco, L. M. Lechuga

Biosensors and Bioelectronics, 117, 47-52, 2018 – DOI: 10.1016/j.bios.2018.05.044

Gold/Silver/Gold Trilayer Films On Nanostructured Polycarbonate Substrates For Direct And Label‐Free Nanoplasmonic Biosensing

G. A. López‐Muñoz, M. C. Estévez, M. Vázquez‐García, M. Berenguel‐Alonso, J. Alonso‐Chamarro, A. Homs‐Corbera, L. M. Lechuga

Journal of Biophotonics, 11(8), e201800043, 2018 – DOI: 10.1002/jbio.201800043

A CO2 Optical Sensor based on Self-Assembled Metal-Organic Framework Nanoparticles

B. Chocarro-Ruiz, J. Pérez-Carvajal, C. Avci, O. Calvo-Lozano, M. I. Alonso, D. Maspoch, L.M. Lechuga

Journal of Materials Chemistry A, 13171-13177, 2018 – DOI: 10.1039/C8TA02767F

2017

Species-specific modulation of food-search behavior by respiration and chemosensation in Drosophila larvae

D. Kim, M. Álvarez, L. M. Lechuga, M. Louis

eLife Sciences Publications, 6, e27057, 2017 – DOI: 10.7554/eLife.27057

Special issue E- MRS 2016, Symposium M: Silicon compatible materials and integrated devices for photonics and optical sensing (GUEST EDITORS)

M. Miritello, L. Rebohle, S. Maier, L. M. Lechuga (Guest Editors)

Journal of Luminescence, 191, part B, 87-138, 2017

Simple, low-cost and timely optical biosensors for the detection of epigenetics biomarkers: the future of cancer diagnosis

C. S. Huertas, L. M. Lechuga

European Medical Journal Oncology, 5, 54-61, 2017

Recent Advances in Nanoplasmonic Biosensors: applications and lab-on-chip integration

G. A. Lopez, M. C. Estevez, M. Soler, L. M. Lechuga

Nanophotonics, 1, 123-136, 2017 – DOI: 10.1515/nanoph-2016-010

Nanophotonic label-free biosensors for environmental monitoring

B. Chocarro-Ruiz, A. Fernández Gavela, S. Herranz, L. M. Lechuga

Current Opinion in Biotechnology, 45, 175-183, 2017 – DOI: 10.1016/j.copbio.2017.03.016

Nanophotonic interferometric immunosensor for label-free and real-time monitoring of chemical contaminants in marine environment

B. Chocarro Ruiz , S. Herranz, A. Fernández Gavela, L. M. Lechuga

Proc. SPIE 10215, Advanced Environmental, Chemical, and Biological Sensing Technologies XIV, 10215, 1021503, 2017 – DOI: 10.1117/12.2256982

Metamirrors based on arrays of silicon nanowires with height gradients

M. A. Otte, A. García-Martin, X. Borrise, B. Sepulveda

Advanced Optical Materials, 5(4), 1600933, 2017 – DOI: 10.1002/adom.201600933

A label-free nanostructured plasmonic biosensor based on Blu-ray discs with integrated microfluidics for sensitive biodetection

G. A. López-Muñoz, M. C. Estevez, E. C. Peláez-Gutierrez, A. Homs-Corbera, M. C. García-Hernandez, J. I. Imbaud, L. M. Lechuga

Biosensors and Bioelectronics, 96, 260–267, 2017 – DOI: 10.1016/j.bios.2017.05.020

Direct and label-free detection of the human growth hormone in urine by an ultrasensitive bimodal waveguide biosensor

A. B. González-Guerrero, J. Maldonado, S. Dante, D. Grajale, L. M. Lechuga

Journal of Biophotonics, 10(1), 61-67, 2017 – DOI: 10.1002/jbio.201600154

An automated optofluidic biosensor platform combining interferometric sensors and injection moulded microfluidics

C. Szydzik, A. Fernández Gavela, S. Herranz, J. Roccisano, M. Knoerzer, P. Thurgood, K. Khoshmanesh, A. Mitchell, L. M. Lechuga

Lab on a Chip, 17(16), 2793-2804, 2017 – DOI: 10.1039/C7LC00524E

Asymmetrically coupled resonators for mass sensing

S. Marquez, M. Alvarez, J. A. Plaza, L. G. Villanueva, C. Domingue, L. M. Lechuga

Applied Physics Letters, 111(11), 113101-113104, 2017 – DOI: 10.1063/1.5003023

Array of Microfluidic Beam Resonators for Density and Viscosity Analysis of Liquids

S. Marquez, M. Alvarez, D. Fariña, A. Homs-Corbera, C. Domínguez, L. M. Lechuga

Journal of Microelectromechanical Systems, 26(4), 749-757, 2017 – DOI: 10.1109/JMEMS.2017.2709944

Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor

C. S. Huertas, S. Domínguez-Zotes, L. M. Lechuga

Scientific Reports, 7, 41368, 2017 – DOI: 10.1038/srep41368

2016

Trends in photonic lab-on-chip interferometric biosensors for point-of-care diagnostics

A. B. Gonzàlez-Guerrero, J. Maldonado, S. Herranz, L. M. Lechuga*

Analytical Methods, 8, 8380-8394, 2016 – DOI: 10.1039/c6ay02972h

Towards the design of universal immunosurfaces for SPR-based assays: A review

E. Mauriz, M. C. García-Fernández, L. M. Lechuga

Trends in Analytical Chemistry, 79, 191-198, 2016 – DOI: 10.1016/j.trac.2016.02.006

Towards an Integrated Optofluidic System for Highly Sensitive Detection of Antibiotics in Seawater Incorporating Bimodal Waveguide Photonic Biosensors and Complex, Active Microfluidics

C. Szydzik, A.Fdez-Gavela, J. Roccisano, S. Herranz, A. Mitchell, L. M. Lechuga

Proc. SPIE 10013, SPIE BioPhotonics Australasia, 10013, 100132C, 2016 – DOI: 10.1117/12.2242885

On the Spot Diagnosis

L. M. Lechuga

The Pathologist, 18, 19-20, 2016

Sensitive and Label-Free Detection of miRNA-145 by Triplex Formation

A. Aviñó, C. S. Huertas, L. M. Lechuga, R. Eritja

Analytical and Bioanalytical Chemistry, 408(3), 885-893, 2016 – DOI: 10.1007/s00216-015-9180-6

Quantitative evaluation of alternatively spliced mRNA isoforms by label-free real-time plasmonic sensing

C. S. Huertas, L. G. Carrascosa, S. Bonnal, J. Valcárcel, L. M. Lechuga

Biosensors and Bioelectronics, 78, 118-125, 2016 – DOI: 10.1016/j.bios.2015.11.023

Prospects of optical biosensors for emerging label-free RNA analysis

L. G. Carrascosa, C. S. Huertas, L. M. Lechuga

Trends in Analytical Chemistry, 80, 177-189, 2016 – DOI: 10.1016/j.trac.2016.02.018

Out-of-plane single-mode photonic microcantilevers for integrated nanomechanical sensing platform

D. Fariña, M. Álvarez, S. Márquez, C. Domínguez, L. M. Lechuga

Sensors and Actuators B: Chemical, 232, 60–67, 2016 – DOI: 10.1016/j.snb.2016.03.041

Last advances in silicon-based optical biosensors

A. Fernández, D. Grajales, J. C. Ramirez, L. M. Lechuga

Sensors, 16(3), 285, 2016 – DOI: 10.3390/s16030285

Label-free SPR detection of gluten peptides in urine for non-invasive celiac disease follow-up

M. Soler, M. C. Estevez, M. L. Moreno, A. Cebolla, L. M. Lechuga.

Biosensors and Bioelectronics, 79, 158–164, 2016 – DOI: 10.1016/j.bios.2015.11.097

Label-free Nanoplasmonic Sensing of Tumor-Associate Autoantibodies for Early Diagnosis of Colorectal Cancer

M. Soler, M. C. Estevez, R. Villar-Vazquez, J. I. Casal, L. M. Lechuga

Analytica Chimica Acta, 930, 31-38, 2016 – DOI: 10.1016/j.aca.2016.04.059

Label-free bimodal waveguide immunosensor for rapid diagnosis of bacterial infections in cirrhotic patients

J. Maldonado, A. B. González-Guerrero, C. Domínguez, L. M. Lechuga

Biosensors and Bioelectronics, 85, 310-316, 2016 – DOI: 10.1016/j.bios.2016.04.095

Fabrication of well-ordered silicon nanopillars embedded in a microchannel via metal-assisted chemical etching: A route towards an opto-mechanical biosensor

V. Solis-Tinoco, S. Marquez, B. Sepulveda, L. M. Lechuga

RSC Advances, 6, 85666-85674, 2016 – DOI: 10.1039/c6ra15485a

Direct and label-free quantification of micro-RNA-181a at attomolar level in complex media using a nanophotonic biosensor

C. S. Huertas, D. Fariña, L. M. Lechuga

ACS Sensors, 1, 748−756, 2016 – DOI: 10.1021/acssensors.6b00162

Configurable Quadrant Photodetector, an Improved Position Sensitive Device (PSD)

R. Esper-Chaín, A. Medina Escuela, D. Fariña, J.R. Sendra

IEEE Sensors Journal, 16-1, 109-119, 2016 – DOI: 10.1109/JSEN.2015.2475597

2015

Tailored Height Gradients in Vertical Nanowire Arrays via Mechanical and Electronic Modulation of Metal-Assisted Chemical Etching

M. A. Otte, V. Solís-Tinoco, P. Prieto, X. Borrisé, L. M. Lechuga, M. U. González, B. Sepulveda

Small, 11(33), 4201–4208, 2015 – DOI: 10.1002/smll.201500175

Study of a low-cost trimodal polymer waveguide for interferometric optical biosensors

J. C. Ramírez, L. M. Lechuga, L. H. Gabrielli, H. E. Hernández-Figueroa

Optic Express, 23, 11985-11994, 2015 – DOI: 10.1364/OE.23.011985

Simulation and characterization of hollow microbridge resonators for label-free biosensing

S. Márquez, M. Álvarez, D. Fariña, C. Domínguez, L. M. Lechuga

Proc. SPIE 9518, Bio-MEMS and Medical Microdevices II, 95180, 95180U, 2015 – DOI: 10.1117/12.2178981

Sensitivity analysis for improving nanomechanical photonic transducers biosensors

D. Fariña, M. Álvarez, S. Márquez, C. Domínguez, L. M. Lechuga

Journal of Physics D: Applied Physics, 48(33), 335401 – DOI: 10.1088/0022-3727/48/33/335401

Novel Nanoplasmonic Biosensor Integrated in a Microfluidic Channel

V. Solis-Tinoco, B. Sepulveda, L. M. Lechuga

Proc. SPIE 9519, Nanotechnology VII, 9519, 95190T – DOI: 10.1117/12.2178990

Linear readout of integrated interferometric biosensors using a periodic wavelength modulation

S. Dante, D. Duval, D. Fariña, A. B. González-Guerrero, L. M. Lechuga

Laser and Photonics Reviews, 9(2), 248-255, 2015 – DOI: 10.1002/lpor.201400216

Highly Sensitive Dendrimer-based Nanoplasmonic Biosensor for Drug Allergy Diagnosis

M. Soler, P. Mesa-Antunez, M. C. Estevez, A. J. Ruiz-Sanchez, M. A. Otte, B. Sepulveda, D. Collado, C. Mayorga, M. J. Torres, E. Perez-Inestrosa, L. M. Lechuga

Biosensors and Bioelectronics, 66, 115-123, 2015 – DOI: 10.1016/j.bios.2014.10.081

Design of a surface plasmon resonance immunoassay for therapeutic drug monitoring of amikacin

A. Losoya-Leal, M. C. Estevez, S. O. Martínez-Chapa, L. M. Lechuga

Talanta, 141, 253-258, 2015 – DOI: 10.1016/j.talanta.2015.04.009

2014

Trends and challenges of refractometric nanoplasmonic biosensors: A review

M. C. Estevez, M. A.Otte, B. Sepulveda, L. M.Lechuga

Analytica Chimica Acta, 806, 55–73 – DOI: 10.1016/j.aca.2013.10.048

Substrate Effect on the Refractive Index Sensitivity of Silver Nanoparticles

E. Martinsson, M. A. Otte, M. Mehdi Shahjamali, B. Sepulveda, D. Aili

The Journal of Physical Chemistry C, 118(42), 24680-24687 – DOI: 10.1021/jp5084086

Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation

L. G. Carrascosa, A. Ali Ibn Sina, R. Palanisamy, B. Sepulveda, M. A. Otte, S. Rauf, M. J. A. Shiddikya, M. Trau

Chemical Communications, 50, 3585-3588 – DOI: 10.1039/C3CC49607D

On-line surface plasmon resonance biosensing of vascular endothelial growth factor signaling in intact-human hepatoma cell lines

E. Mauriz, S. Carbajo-Pescador, R. Ordñez, M. C. García-Fernández, J. L. Mauriz, L. M. Lechuga, J. González-Gallego

Analyst, 139(6), 1426-1435, 2014 – DOI: 10.1039/C3AN02211K

The effects of lipids and surfactants on TLR5-proteoliposome functionality for flagellin detection using surface plasmon resonance biosensing

Y. Olguín, L. G. Carrascosa, L. M. Lechuga, M. Young

Talanta, 126, 136-144, 2014 – DOI: 10.1016/j.talanta.2014.03.065

Direct Detection of Protein Biomarkers in Human Fluids Using Site-Specific Antibody Immobilization Strategies

M. Soler, M. C. Estevez, M. Álvarez, M. A. Otte, B. Sepulveda, L. M. Lechuga

Sensors, 14(2), 2239-2258, 2014 – DOI: 10.3390/s140202239

2013

Spatial Distribution of Optical Near-Fields in Plasmonic Gold Sphere Segment Voids

M. Schmidt, N. G. Tognalli, M. A. Otte, M. I. Alonso, B. Sepulveda, A. Fainstein, A. R. Goñi

Plasmonics, 8(2), 921-930 – DOI: 10.1007/s11468-013-9491-4

Site-directed antibody immobilization using a protein A-gold binding domain fusion protein for enhanced SPR immunosensing

E. de Juan-Franco, A. Caruz, J. R. Pedrajas, L. M. Lechuga

Analyst, 138(7), 2023-2031 – DOI: 10.1039/c3an36498d

Real-time detection of the chemokine CXCL12 in urine samples by surface plasmon resonance

A. Calle, A. Sánchez, L. M. Lechuga, M. A. Otte, G. Armelles, J. M. Rodríguez-Frade, M. Mellado

Talanta, 109, 209-215 – DOI: 10.1016/j.talanta.2013.02.018

Implementation of a SPR immunosensor for the simultaneous detection of the 22K and 20K hGH isoforms in human serum samples

E. de Juan-Franco, J. M. Rodríguez-Frade, M. Mellado, L. M. Lechuga

Talanta, 114, 268-275 – DOI: 10.1016/j.talanta.2013.04.042

Grating couplers integrated on Mach-Zehnder interferometric biosensors operating in the visible range

D. Duval, J. Osmond, S. Dante, C. Domínguez, L. M. Lechuga

IEEE Photonics Journal, 5(2), 3700108/1-8 – DOI: 10.1109/JPHOT.2013.2251873

Development of a surface plasmon resonance and nanomechanical biosensing hybrid platform for multiparametric reading

M. Álvarez, D. Fariña, A. M. Escuela, J. R. Sendra, L. M. Lechuga

Review of Scientific Instruments, 84, 015008 – DOI: 10.1063/1.4789430

Detection of flagellin by interaction with human recombinant TLR5 immobilized in liposomes

Y. Olguín, P. Villalobos, L. G. Carrascosa, M. Young, E. Valdez, L. M. Lechuga, R. Galindo

Analytical and Bioanalytical Chemistry, 405(4), 1267-1281 – DOI: 10.1007/s00216-012-6523-4

A comparative study of in-flow and micro-patterning biofunctionalization protocols for nanophotonic silicon-based biosensors

A. B. González-Guerrero, M. Alvarez, A. García Castaño, C. Domínguez, L. M. Lechuga

Journal of Colloid and Interface Science, 393, 402-410 – DOI: 10.1016/j.jcis.2012.10.040

2012 Breakthroughs in Lab-on-a-chip & Optical biosensors

D. Duval, L. M. Lechuga

IEEE Photonics Journal, 5(2), 0700906/1-6 – DOI: 10.1109/JPHOT.2013.2250943

2012

Transparent conductive oxides for active hybrid metamaterial devices

M. Abb, B. Sepulveda, H. M. H. Chong, O. L. Muskens

Journal of Optics, 14(11), 114007 – DOI: 10.1088/2040-8978/14/11/114007

Towards a complete Lab-On-Chip system using integrated Mach-Zehnder interferometers

S. Dante, D. Duval, A. B. González-Guerrero, J. Osmond, K. Zinoviev, B. Sepúlveda, C. Mínguez, L. M. Lechuga

Óptica Pura y Aplicada, 45, 87-95 – DOI: 10.7149/OPA.45.2.87

Silicon Photonic Based Biosensors: The Future of Lab-on-a-Chip Diagnostic Devices

D. Duval, A. B. González-Guerrero, L. M. Lechuga

IEEE Photonics Society Newsletter, 26(4), 5-8

Sensitive and label-free biosensing of RNA with predicted secondary structures by a triplex affinity capture method

L. G. Carrascosa, S. Gómez-Montes, A. Aviñó, A. Nadal, M. Pla, R. Eritja, L. M. Lechuga

Nucleic Acids Research, 40(8), e56 – DOI: 10.1093/nar/gkr1304

Optical Biochemical and Chemical Sensors (Editorial)

L. M. Lechuga

Analytical and Bioanalytical Chemistry, 404, 2795 – DOI: 10.1007/s00216-012-6442-4

Nanophotonic lab-on-chip platforms including novel bimodal interferometers, microfluidics and grating couplers

D. Duval, A. B. González-Guerrero, S. Dante, J. Osmond, R. Monge, L. J. Fernández, K. E. Zinoviev, C. Domínguez, L. M. Lechuga

Lab Chip, 12, 1987-1994 – DOI: 10.1039/C2LC40054E

Investigation of fabrication and resonant optical coupling in various 2D micro-resonator structures in a UV210 polymer

D. Pluchon, N. Huby, H. Lhermite, D. Duval, B. Bêche

Journal of Micromechanics and Microengineering, 22, 085016-1/8 – DOI: 10.1088/0960-1317/22/8/085016

Interferometric waveguide biosensor based on Si-technology for point-of-care diagnostic

D. Duval, A. B. González-Guerrero, S. Dante, L. M. Lechuga.

Proc. SPIE 8431, Silicon Photonics and Photonic Integrated Circuits III, 8431, 84310P – DOI: 10.1117/12.922139

Integrated optical devices for lab-on-a-chip biosensing applications

M. C. Estevez, M. Alvarez, L. M. Lechuga

Laser and Photonics Reviews, 6(4), 463-487 – DOI: 10.1002/lpor.201100025

Indirect competitive immunoassay for the detection of fungicide Thiabendazole in whole orange samples by Surface Plasmon Resonance

M. C. Estevez, J. Belenguer, S. Gómez, J. Miralles, A. M. Escuela, A. Montoya, L. M. Lechuga

Analyst, 137(23), 5659-5665 – DOI: 10.1039/c2an36094b

Enhanced light extraction in ITO-free OLEDs using double-sided printed electrodes

V. Reboud, A. Z. Khokhar, B. Sepúlveda, D. Dudek, T. Kehoe, J. Cuffe, N. Kehagias, M. Lira-Cantu, N. Gadegaard, V. Grasso, V. Lambertini, C. M. Sotomayor Torres

Nanoscale, 4(11), 3495-3500 – DOI: 10.1039/C2NR12068B

Direct Surface Plasmon Resonance immunosensing of Pyraclostrobin residues in untreated fruit juices

E. Mauriz, C. García-Fernández, J. V. Mercader, A. Abad-Fuentes, A. Medina-Escuela, L. M. Lechuga

Analytical and Bioanalytical Chemistry, 404(10), 2877-2886 – DOI: 10.1007/s00216-012-6321-z

All-optical phase modulation for integrated interferometric biosensors

S. Dante, D. Duval, B. Sepulveda, A. B. González-Guerrero, J. R. Sendra, L. M. Lechuga

Optic Express, 20, 7195-7205 – DOI: 10.1364/OE.20.007195

2011

Technical Advance: Surface plasmon resonance-based analysis of CXCL12 binding using immobilized lentiviral particles

B. Vega, L. Martínez Muñoz, B. L. Holgado, P. Lucas, J. M. Rodríguez-Frade, A. Calle, J. L. Rodríguez-Fernández, L. M. Lechuga, J. F. Rodríguez, R. Gutiérrez-Gallego, M. Mellado

Journal of Leukocyte Biology, 90(2), 399-408 – DOI: 10.1189/jlb.1010565

Suitable combination of noble/ferromagnetic metal multilayers for enhanced magneto-plasmonic biosensing

D. Regatos, B. Sepúlveda, D. Fariña, L. G. Carrascos, L. M. Lechuga

Optic Express, 19(9), 8336-8346 – DOI: 10.1364/OE.19.008336

Polypeptide Folding-Mediated Tuning of the Optical and Structural Properties of Gold Nanoparticle Assemblies

D. Aili, P. Gryko, B. Sepulveda, J. A. G. Dick, N. Kirby, R. Heenan, L. Baltzer, B. Liedberg, M. P. Ryan, M. M. Stevens

Nano Letters, 11(12), 5564-5573 – DOI: 10.1021/nl203559s

Light propagation in single mode polymer nanotubes integrated on photonic circuits

N. Huby, J. L. Duvail, D. Duval, D. Pluchon, B. Bêche

Applied Physics Letters, 99(11), 113302 – DOI: 10.1063/1.3637043

Integrated Bimodal Waveguide Interferometric Biosensor for Label-Free Analysis

K. E. Zinoviev, A. B. González-Guerrero, C. Domínguez, L. M. Lechuga

Journal of Lightwave Technology, 29(13), 1926-1930 – DOI: 10.1109/JLT.2011.2150734

Improved Biosensing with Novel Suspended Nanodisks

B. Otte, M. C. Estévez, L. G. Carrascosa, A. B. González-Guerrero, L. M. Lechuga, B. Sepúlveda

Journal of Physical Chemistry C, 115(13), 5344-5351 – DOI: 10.1021/jp110363a

Guiding Light in Monolayers of Sparse and Random Plasmonic Meta-atoms

M. A. Otte, M. C. Estévez, D. Regatos, L. M. Lechuga, B. Sepúlveda

ACS Nano, 5(11), 9179-9186 – DOI: 10.1021/nn203432z

Biosensores opto-mecánicos basados en microcantilevers

D. Fariña, M. Álvarez, J. R. Sendra, L. M. Lechuga

Intekhnia, 6(1), 45-55

2010

Understanding the role of thiol and disulfide self-assembled DNA receptor monolayers for biosensing applications

L. G. Carrascosa, L. Martínez, Y. Huttel, E. Román, L. M. Lechuga

European Biophysics Journal, 39(10), 1433-1444 – DOI: 10.1007/s00249-010-0599-6

Sensia, S. L.

L. M. Lechuga

Actualidad Analítica. Boletín de la Sociedad Española de Química Analítica, 32, 8

Plasmon-Induced Magneto-Optical Activity in Nanosized Gold Disks

B. Sepúlveda, J. B. González-Díaz, A. García-Martın, L. M. Lechuga, G. Armelles

Physical Review Letters, 104(14), 147401/1-4 – DOI: 10.1103/PhysRevLett.104.147401

Optical Forces in Plasmonic Nanoparticle Dimers

V. D. Miljkovic, T. Pakizeh, B. Sepulveda, P. Johansson, M. Kall

Journal of Physical Chemistry C, 114(16), 7472-7479 – DOI: 10.1021/jp911371r

Microcantilever-based platforms as biosensing tools

M. Alvarez, L. M. Lechuga

Analyst, 135(5), 827-836 – DOI: 10.1039/b908503n

Influence of the linker type on the Au-S binding properties of thiol and disulfide-modified DNA self-assembly on polycrystalline gold

L. Martínez, L. G. Carrascosa, Y. Huttel, L. M. Lechuga, E. Román

Physical Chemistry Chemical Physics, 12(13), 3301-3308 – DOI: 10.1039/b924504a

Identification of the Optimal Spectral Region for Plasmonic and Nanoplasmonic Sensing

M. A. Otte, B. Sepúlveda, W. Ni, J. Pérez-Juste, L. M. Liz-Marzán, L. M. Lechuga

ACS Nano, 4(1), 349-357 – DOI: 10.1021/nn901024e

Cobalt dependence of the magneto-optical response in magnetoplasmonic nanodisks

J. B. González-Díaz, B. Sepulveda, A. García-Martín, G. Armelles

Applied Physics Letters, 97(4), 043114/1-4 – DOI: 10.1063/1.3474617

Au/Fe/Au multilayer transducers for Magneto-Optic Surface Plasmon Resonance sensing

D. Regatos, D. Fariña, A. Calle, A. Cebollada, B. Sepúlveda, G. Armelles, L. M. Lechuga

Journal of Applied Physics, 108(5), 054502/1-6 – DOI: 10.1063/1.3475711

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