The aim of this research line is the development of highly sensitive multiplexed biosensing platforms based on the Localized Surface Plasmon Resonance (LSPR) of metal nanostructures.
We have analyzed three important features to improve the performance of nanoplasmonic sensors:
- The spectral dependence of the biosensing figure of merit (Link to ACS Nano 4, 349, 2010
- The near field distribution of plasmonic nanostructures, interaction with the substrate and improvement of the access of the receptors and analytes to the hot-spots (Link to J. Phys. Chem. C 115, 5344, 2011)
- Far-field coupling between nanostructures to drastically improve the signal-to-noise ratio and speed of biosensing measurements (Link to ACS Nano 5, 9179, 2011)
- Modulation methods to improve the signal to noise ratio of the biosensing measurements: magneto-plasmonic modulation (Link to Phys. Rev. Lett. 104, 147401, 2010; App. Phys. Lett. 97, 043114, 2010) and all-optical modulation mechanisms (Link to Otto Paper)
- Biofunctionalization and self-assembled techniques with de novo designed polypeptides. (Link to Nano Lett. 11, 5564, 2011)
- Multiplexed analytic device with integrated microfluidics.
- Novel all-optical modulation schemes
- Oriented biofunctionalization protocols with improved resistance to non-specific absorption of biomolecules.