Recent Advances in Nanoplasmonic Biosensors: applications and lab-on-chip integration
G. A. Lopez, M.C Estevez, M. Soler and L. M. Lechuga
Nanophotonics,6, 1, 2017, 123-136 - DOI: 10.1515/nanoph-2016-010
Abstract: Motivated by the recent progress in the nanofabrication field and the increasing demand for cost effective, portable and easy-of-use point-of-care platforms, Localized Surface Plasmon Resonance (LSPR) biosensors have been subjected to a great scientific interest in the last few years. The progress in the research of this nanoplasmonics technology is remarkable, not only from a nanostructure fabrication point of view, but also in the complete development and integration of operative devices and their application. Potential benefits that LSPR biosensors can offer such as sensor miniaturization, multiplexing opportunities and enhanced performances has quickly positioned them as an interesting candidate in the design of lab-on-a-chip (LOC) optical biosensor platforms. This review covers specifically the most significant achievements occurring in recent years towards the integration of this technology in compact devices, with views of obtaining LOC devices. We also discuss the most relevant examples of the use of the nanoplasmonic biosensors for real bioanalytical and clinical applications, covering from the assay development and validation, to the identification of the implications, requirements and challenges to be surpassed in order to achieve fully operative devices.