Nanophotonic lab-on-chip platforms including novel bimodal interferometers, microfluidics and grating couplers
D. Duval , A. B. González-Guerrero , S. Dante , J. Osmond, R. Monge , L. J. Fernández , K. E. Zinoviev , C. Domínguez and L. M. Lechuga
Lab Chip, 12, 2012, 1987-1994 - DOI: 10.1039/C2LC40054E
Abstract: One of the main limitations for achieving truly lab-on-a-chip (LOC) devices for point-of-care diagnosis is the incorporation of the “on-chip” detection. Indeed, most of the state-of-the-art LOC devices usually require complex read-out instrumentation, losing the main advantages of portability and simplicity. In this context, we present our last advances towards the achievement of a portable and label-free LOC platform with highly sensitive “on-chip” detection by using nanophotonic biosensors. Bimodal waveguide interferometers fabricated by standard silicon processes have been integrated with sub-micronic grating couplers for efficient light in-coupling, showing a phase resolution of 6.6 × 10−4 × 2π rad and a limit of detection of 3.3 × 10−7refractive index unit (RIU) in bulk. A 3D network of SU-8 polymer microfluidics monolithically assembled at the wafer-level was included, ensuring perfect sealing and compact packaging. To overcome some of the drawbacks inherent to interferometric read-outs, a novel all-optical wavelength modulation system has been implemented, providing a linear response and a direct read-out of the phase variation. Sensitivity, specificity and reproducibility of the wavelength modulated BiMW sensor has been demonstrated through the label-free immunodetection of the human hormone hTSH at picomolar level using a reliable biofunctionalization process.