Interferometric waveguide biosensor based on Si-technology for point-of-care diagnostic
D. Duval, A. B. González-Guerrero, S. Dante, and L. M. Lechuga.
Proc. SPIE, 8431, 2012, 84310P - DOI: 10.1117/12.922139
Abstract: Silicon photonic biosensors based on evanescent wave detection have revealed themselves as the most promising candidates for achieving truly point-of-care devices as they can overcome the limitations of current analytical techniques. Advantages such as miniaturization, extreme sensitivity, robustness, reliability, potential for multiplexing and mass production at low cost can be offered. Among the existing integrated optical sensors, the interferometric ones are the most attractive due to their extreme sensitivity for label-free and real-time evaluations with detection limits close to 10-7- 10-8 in bulk refractive index. In this article we will review the recent progress in the most common interferometric waveguide biosensors (Mach-Zehnder interferometers, Young interferometers, Hartman interferometers, dual polarization interferometers and bimodal optical waveguides). In particular, we will focus on the description of their optical structures and their applicability for bioanalytical detection.